Susceptibility of the ovariectomized hen to cholesterol-induced coronary atherogenesis.

Ovariectomy, social status, and atherosclerosis in cynomolgus monkeys.

Evidence is contradictory regarding the effects of natural or surgical menopause on "female protection" against coronary artery atherosclerosis. We evaluated atherosclerosis, plasma lipids, blood pressure, and carbohydrate tolerance in 21 ovariectomized and 23 intact female cynomolgus macaques fed a moderately atherogenic diet for 30 months. We also evaluated the influence of social dominance s...

Inhibition of cholesterol-induced coronary atherogenesis in the egg-producing hen.

The experimental designs and technics were generally in accord with the standardized procedures developed by the department's atherosclerosis research group.3 Altogether, four series of chronic experiments were completed, varying in duration from 5 to 11 weeks, and utilizing a total of 129 fully grown, sexually mature chickens, age 24 to 34 weeks at the onset of the study (table 1). Essentially...

Stress and Atherogenesis: Smooth Muscle Cell Mitogenic Activity and other Biochemical Changes Associated with Sera of \"Stressed\" Subjects

The proliferation of smooth muscle cells in the arterial wall (VSMC) is considered to play a key role in the development of atherosclerosis. To investigate the possible contribution of "stress" (experimentally-induced) to this process, blood from healthy volunteers, ages 21 to 65, screened to exclude major risk factors for coronary heart disease, was assayed for mitogenic activity after the sub...

Estrogen-induced regression of coronary atherosclerosis in cholesterol-fed chicks.

The present study demonstrates that estrogens reverse previously induced coronary atherosclerosis in cholesterol-fed cockerels, despite the continued presence of the atherogenic stimulus in the diet. Aorta atherogenesis remains unaffected. Hypercholesterolemia is moderately enhanced by estrogen administration; total cholesterol-lipid phosphorus (C/P) ratios are depressed to normal levels, conse...

Effect of hypothyroidism on estrogen-induced inhibition of coronary atherogenesis in cholesterol-fed cockerels.